Leaky Brain manifests as multiple signs and symptoms, so pay attention to these as opposed to ignoring them:
- ADD/ADHD/Autism spectrum disorders
- Brain fog or difficulty concentrating
- Chronic fatigue that does not improve with rest or sleep
- Headaches or migraines that come on suddenly become worse with standing, and grow more severe as the day progresses
- Memory loss or another cognitive decline which may lead to dementia and Alzheimer's disease
- Mood disorders, particularly anxiety, depression, and schizophrenia
- Peripheral neuropathy or muscular sclerosis
It is important not to ignore these signs and symptoms because those living with Leaky Brain are at an increased risk of developing neurological or psychiatric conditions. Many of these conditions are considered signs and symptoms of Leaky Brain, but they may also be counted among the causes of Leaky Brain.
Leaky Brain Can Cause:
Reduced mental ability, difficulty concentrating or multitasking, short and long-term memory loss, collectively referred to as brain fog, via prolonged activation of mast cells
An increase in VCAM-1 adhesion molecules which allow beta-amyloid peptides to accumulate in the brain forming plaques around nerve cells interrupting their function and blocking their nutrient supply, a process more commonly known as Alzheimer's disease.
Changes in the transport of molecules between the brain and bloodstream which allow Huntington Disease to progress and decrease the number of proteins available to form tight junctions within the BBB.
Brain inflammation and oxidative damage, increasing the risk for schizophrenia, by destroying BBB-supporting, astroglial cells and triggering the release of toxic inflammatory agents further breaking down the BBB.
Insufficient blood flow to the brain as well as abnormal brain activity, as seen in patients living with depression, because extended periods of brain inflammation disable adequate nerve function similar to schizophrenia.
Diseases that Contribute to Leaky Brain include:
Multiple Sclerosis – People with this disease have high levels of MMP9 which damages nerves along with significant albumin in the brain which promotes inflammation and makes nerves more susceptible to glutamate toxicity.
Autism – More of a reciprocal relationship, Autism can cause Leaky Brain and vice versa; BBB permeability is higher in people diagnosed on the Autism spectrum thereby tolerating mast cell activation and inflammation.
Seizures & Epilepsy – Seizures interrupt BBB function, and prolonged seizures permit inflammation and albumin to rise in the brain increasing BBB permeability which can lead to chronic epilepsy.